Candida albicans is an important pathogenic fungus of humans, causing a range of infections. These infections are usually treated with antifungal drugs that target sterol metabolism. Resistance to these antifungals can result from overexpression of sterol biosynthetic genes. Therefore it is of interest to understand transcriptional regulation of sterol biosynthesis in C. albicans. Recently two reports [Silver, Oliver and White (2004) Eukaryot. Cell 3, 1391–1397; MacPherson, Akache, Weber, De Deken, Raymond and Turcotte (2005) Antimicrob. Agents Chemother. 49, 1745–1752] have identified and characterized a single C. albicans transcription factor gene UPC2 that regulates sterol metabolism. The details of both characterizations are compared and contrasted. These reports extend our understanding of sterol regulation in this important human pathogen.
Conference Article| October 26 2005
Regulation of sterol metabolism in Candida albicans by the UPC2 gene
T.C. White 1
*Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, U.S.A.
†Seattle Biomedical Research Institute, Seattle, WA 98195, U.S.A.
1To whom correspondence should be addressed, at Seattle Biomedical Research Institute, 307 Westlake Ave., N., Suite 500, Seattle, WA 98109-5219, U.S.A. (email email@example.com).
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T.C. White, P.M. Silver; Regulation of sterol metabolism in Candida albicans by the UPC2 gene. Biochem Soc Trans 26 October 2005; 33 (5): 1215–1218. doi: https://doi.org/10.1042/BST0331215
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