Bovine heart cytochrome c oxidase is a large multi-component membrane protein containing several phospholipids. X-ray structures of this enzyme at high resolution, determined recently, show a trigonal planar structure of CuB site in the O2 reduction site, which could contribute critically to the four-electron reduction of O2 bound at haem a3, and a hydrogen bond network, through which the proton pump is driven by haem a. The possible roles of phospholipids in the enzyme functions are discussed.
Conference Article| October 26 2005
Reaction mechanism and phospholipid structures of bovine heart cytochrome c oxidase
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S. Yoshikawa; Reaction mechanism and phospholipid structures of bovine heart cytochrome c oxidase. Biochem Soc Trans 26 October 2005; 33 (5): 934–937. doi: https://doi.org/10.1042/BST0330934
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