Actin reorganization is a tightly regulated process that co-ordinates complex cellular events, such as cell migration, chemotaxis, phagocytosis and adhesion, but the molecular mechanisms that underlie these processes are not well understood. SCAR (suppressor of cAMP receptor)/WAVE [WASP (Wiskott–Aldrich syndrome protein)-family verprolin homology protein] proteins are members of the conserved WASP family of cytoskeletal regulators, which play a critical role in actin dynamics by triggering Arp2/3 (actin-related protein 2/3)-dependent actin nucleation. SCAR/WAVEs are thought to be regulated by a pentameric complex which also contains Abi (Abl-interactor), Nap (Nck-associated protein), PIR121 (p53-inducible mRNA 121) and HSPC300 (haematopoietic stem progenitor cell 300), but the structural organization of the complex and the contribution of its individual components to the regulation of SCAR/WAVE function remain unclear. Additional features of SCAR/WAVE regulation are highlighted by the discovery of other interactors and distinct complexes. It is likely that the combinatorial assembly of different components of SCAR/WAVE complexes will prove to be vital for their roles at the centre of dynamic actin reorganization.
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Conference Article|
October 26 2005
Regulation of actin assembly by SCAR/WAVE proteins Available to Purchase
N. Ibarra;
N. Ibarra
1School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
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A. Pollitt;
A. Pollitt
1School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
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R.H. Insall
R.H. Insall
1
1School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
1To whom correspondence should be addressed (email [email protected]).
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Publisher: Portland Press Ltd
Received:
August 01 2005
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2005 The Biochemical Society
2005
Biochem Soc Trans (2005) 33 (6): 1243–1246.
Article history
Received:
August 01 2005
Citation
N. Ibarra, A. Pollitt, R.H. Insall; Regulation of actin assembly by SCAR/WAVE proteins. Biochem Soc Trans 26 October 2005; 33 (6): 1243–1246. doi: https://doi.org/10.1042/BST0331243
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