Centaurin β4 proteins are products of the DDEF1 (development and differentiation-enhancing factor 1) locus on human chromosome 8q24.1-24.2. Recent reports have indicated that this region and its products are amplified during development of several human cancers. Centaurins are GAPs (GTPase-activating proteins) that, together with GEFs (guanine nucleotide-exchange factors), regulate cyclic activation of Arfs (ADP-ribosylation factors), members of the Ras GTPase superfamily. Centaurin β4 proteins associate with a variety of cellular signalling components implicated in control of growth, survival and movement and may act to direct assembly and/or disassembly of molecular complexes in concert with Arf, lipid and protein phosphorylation signalling pathways.
Conference Article| October 26 2005
Centaurin β4 in cancer
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R.K. Martin, T.R. Jackson; Centaurin β4 in cancer. Biochem Soc Trans 26 October 2005; 33 (6): 1282–1284. doi: https://doi.org/10.1042/BST0331282
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