A widely studied example of vertebrate plasticity is LTP (long-term potentiation), the persistent synaptic enhancement that follows a brief period of coinciding pre- and post-synaptic activity. During LTP, different kinases, including CaMKII (calcium/calmodulin-dependent protein kinase II) and protein kinase A, become activated and play critical roles in induction and maintenance of enhanced transmission. Biochemical analyses have revealed several regulated phosphorylation sites in the AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor subunits, GluR1 and GluR4. The regulated insertion of these receptors is a key event in the induction of LTP. Here, we discuss the phosphorylation of GluR1 and GluR4 and its role in receptor delivery and neuronal plasticity.
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October 2005
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Conference Article|
October 26 2005
AMPA receptor phosphorylation during synaptic plasticity
J. Boehm;
J. Boehm
1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, U.S.A.
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R. Malinow
R. Malinow
1
1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, U.S.A.
1To whom correspondence should be addressed (email [email protected]).
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Publisher: Portland Press Ltd
Received:
June 17 2005
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2005 The Biochemical Society
2005
Biochem Soc Trans (2005) 33 (6): 1354–1356.
Article history
Received:
June 17 2005
Citation
J. Boehm, R. Malinow; AMPA receptor phosphorylation during synaptic plasticity. Biochem Soc Trans 26 October 2005; 33 (6): 1354–1356. doi: https://doi.org/10.1042/BST0331354
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