The Trx (thioredoxin) and Grx (glutaredoxin) systems control cellular redox potential, keeping a reducing thiol-rich intracellular state, which on generation of reactive oxygen species signals through thiol redox control mechanisms. Here, we give a brief overview of the human Trx and Grx systems. The main part focuses on our current knowledge about mitochondrial Grx2, which facilitates mitochondrial redox homoeostasis during oxidative stress-induced apoptosis.
Thiol redox control via thioredoxin and glutaredoxin systems
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A. Holmgren, C. Johansson, C. Berndt, M.E. Lönn, C. Hudemann, C.H. Lillig; Thiol redox control via thioredoxin and glutaredoxin systems. Biochem Soc Trans 26 October 2005; 33 (6): 1375–1377. doi: https://doi.org/10.1042/BST0331375
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