Nitric oxide (NO) can induce cell death; however, NO-induced cell death may be dependent/conditional on factors other than NO itself. Whether NO kills a particular cell depends on the amount of NO, source of NO, time of exposure to NO, cell type and the levels of other factors including, particularly oxygen, superoxide, H2O2, antioxidants, thiols and glycolysis.
Conference Article| October 26 2005
What else has to happen for nitric oxide to induce cell death?
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V. Borutaite, G. Brown; What else has to happen for nitric oxide to induce cell death?. Biochem Soc Trans 26 October 2005; 33 (6): 1394–1396. doi: https://doi.org/10.1042/BST0331394
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