Overcoming DNA replication fork blocks is essential for completing genome duplication and cell division. Archaea and eukaryotes drive replication using essentially the same protein machinery. Archaea may be a valuable resource for identifying new helicase components at advancing forks and/or in replication-restart pathways. As described here, these may be relevant to understanding genome instability in metazoans.
Conference Article| October 26 2005
Helicases that interact with replication forks: new candidates from archaea
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E.L. Bolt; Helicases that interact with replication forks: new candidates from archaea. Biochem Soc Trans 26 October 2005; 33 (6): 1471–1473. doi: https://doi.org/10.1042/BST0331471
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