We describe cellular engineering for the creation of multiple new cellular modules each composed of an orthogonal ribosome and orthogonal mRNA. These modules operate independently of the endogenous ribosome and mRNA. We discuss some of the applications of orthogonal pairs and highlight the expression of Boolean logic in gene regulation using multiple orthogonal pairs.
Conference Article| March 20 2006
Synthesizing cellular networks from evolved ribosome–mRNA pairs
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O. Rackham, J.W. Chin; Synthesizing cellular networks from evolved ribosome–mRNA pairs. Biochem Soc Trans 1 April 2006; 34 (2): 328–329. doi: https://doi.org/10.1042/BST0340328
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