The receptor tyrosine kinase Met and its ligand HGF/SF (hepatocyte growth factor/scatter factor) are essential in the signalling pathways required for embryogenesis and tissue regeneration. Aberrant signalling of this complex is also a feature of many tumours and appears to contribute to the growth, invasiveness and metastasis of both carcinomas and sarcomas. HGF/SF, like many other angiogenic growth factors, employs heparan sulphate as co-receptor. The role of this interaction has not been completely defined but appears to be physiologically relevant. Thus the presence of heparin increases the potency of HGF/SF in experiments with cells in culture leading to elevated downstream signalling effects and, although not vital for the Met–HGF/SF interaction, heparin or heparan sulphate is essential for the activity of certain isoforms of HGF/SF, such as NK1 and NK2. Here, we summarize the progress made in understanding the interaction between heparin and heparan sulphate and NK1, NK2 and HGF/SF and we discuss their role in HGF/SF–Met signalling.
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Conference Article|
May 22 2006
Signalling by HGF/SF and Met: the role of heparan sulphate co-receptors
L.E. Kemp;
L.E. Kemp
*MRC Centre, Hills Road, Cambridge CB2 2QH, U.K.
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B. Mulloy;
B. Mulloy
†National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QC, U.K.
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E. Gherardi
E. Gherardi
1
*MRC Centre, Hills Road, Cambridge CB2 2QH, U.K.
1To whom correspondence should be addressed (email egherard@mrc-lmb.cam.ac.uk).
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Publisher: Portland Press Ltd
Received:
December 20 2005
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2006 The Biochemical Society
2006
Biochem Soc Trans (2006) 34 (3): 414–417.
Article history
Received:
December 20 2005
Citation
L.E. Kemp, B. Mulloy, E. Gherardi; Signalling by HGF/SF and Met: the role of heparan sulphate co-receptors. Biochem Soc Trans 1 June 2006; 34 (3): 414–417. doi: https://doi.org/10.1042/BST0340414
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