HS (heparan sulphate) plays a key role in angiogenesis, by interacting with growth factors required in the process. It has been proposed that HS controls the diffusion, and thus the availability, of platelet-derived growth factor B that is needed for pericyte recruitment around newly formed capillaries. The present paper summarizes our studies on the importance of HS structure in this regulatory process.
Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment
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S. Kurup, A. Abramsson, J.P. Li, U. Lindahl, L. Kjellen, C. Betsholtz, H. Gerhardt, D. Spillmann; Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment. Biochem Soc Trans 1 June 2006; 34 (3): 454–455. doi: https://doi.org/10.1042/BST0340454
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