The biochemical aspects of cGMP signalling are well known, although in vivo roles of cGMP have only been recently discovered through work in genetic model organisms. The Drosophila melanogaster Malpighian (renal) tubule has been used to address the roles of cGMP in epithelial function. Here, we describe some of this work and outline recent progress in understanding the organotypic function of novel phosphodiesterases encoded by the D. melanogaster genome.
Conference Article| July 21 2006
cGMP signalling in a transporting epithelium
S.-A. Davies 1
1Division of Molecular Genetics, Institute of Biomedical and Life Sciences, University of Glasgow, Dumbarton Road, Glasgow G11 6NU, U.K.
1To whom correspondence should be addressed (email firstname.lastname@example.org).
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S.-A. Davies, J.P. Day; cGMP signalling in a transporting epithelium. Biochem Soc Trans 1 August 2006; 34 (4): 512–514. doi: https://doi.org/10.1042/BST0340512
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