Homologous recombination is essential for accurate chromosome segregation during meiosis in most sexual organisms. Meiotic recombination is initiated by the formation of DSBs (DNA double-strand breaks) made by the Spo11 protein. We review here recent findings pertaining to protein–protein interactions important for DSB formation, the mechanism of an early step in the processing of Spo11-generated DSBs, and regulation of DSB formation by protein kinases.
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Conference Article| July 21 2006
Initiation of meiotic recombination by formation of DNA double-strand breaks: mechanism and regulation
S. Keeney 1
*Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., Box 97, New York, NY 10021, U.S.A.
†Gerstner Sloan-Kettering Graduate School of Biomedical Sciences, 1275 York Ave., Box 441, New York, NY 10021, U.S.A.
1To whom correspondence should be addressed, at Molecular Biology Program, Memorial Sloan-Kettering Cancer Center (email email@example.com).
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S. Keeney, M.J. Neale; Initiation of meiotic recombination by formation of DNA double-strand breaks: mechanism and regulation. Biochem Soc Trans 1 August 2006; 34 (4): 523–525. doi: https://doi.org/10.1042/BST0340523
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