Meiotic recombination in humans is thought to occur as part of the resolution of DSBs (double-strand breaks). The repair of DSBs potentially leads to biases in DNA repair that can distort the population frequency of the alleles at single-nucleotide polymorphisms. Genome-wide variation data provide evidence for a weak fixation bias in favour of G and C alleles that is strongest at the centre of inferred recombination hotspots.
Conference Article| July 21 2006
Human polymorphism around recombination hotspots
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C.C.A. Spencer; Human polymorphism around recombination hotspots. Biochem Soc Trans 1 August 2006; 34 (4): 535–536. doi: https://doi.org/10.1042/BST0340535
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