It emerges that myosin Va plays multiple roles in the trafficking of SGs (secretory granules). In addition to a function in the capture and transport of newly formed SGs in the F-actin-rich cortex, myosin Va is implicated in late transport events of these organelles, which precede their exocytosis. Consistent with these roles, interactions of myosin Va with an array of well-known proteins involved in regulated protein secretion have been documented.
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Conference Article| October 25 2006
The role of myosin Va in secretory granule trafficking and exocytosis
H.-H. Gerdes 1
*Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
†Department of Neurobiology, ICN (Interdisciplinary Center for Neurosciences), University of Heidelberg, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany
1To whom correspondence should be addressed (email firstname.lastname@example.org).
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T.W. Eichler, T. Kögel, N.V. Bukoreshtliev, H.-H. Gerdes; The role of myosin Va in secretory granule trafficking and exocytosis. Biochem Soc Trans 1 October 2006; 34 (5): 671–674. doi: https://doi.org/10.1042/BST0340671
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