FOXO (forkhead box O) transcription factors are crucial regulators of cell fate. This function of FOXO proteins relies on their ability to control diverse and at times, opposing cellular functions, such as proliferation, differentiation, DNA repair, defence against oxidative stress damage and apoptosis, in response to hormones, growth factors and other environmental cues. This review discusses our current understanding of the regulation and role of FOXO transcription factors in determining cell fate and highlights their relevance to tumorigenesis and drug resistance.
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Conference Article| October 25 2006
FOXO transcription factors: key regulators of cell fate
E.W.-F. Lam 1
1Cancer Research UK Laboratories, Department of Oncology, MRC Cyclotron Building, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, U.K.
1To whom correspondence should be addressed (email firstname.lastname@example.org).
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E.W.-F. Lam, R.E. Francis, M. Petkovic; FOXO transcription factors: key regulators of cell fate. Biochem Soc Trans 1 October 2006; 34 (5): 722–726. doi: https://doi.org/10.1042/BST0340722
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