We have established a novel role for the second messenger DAG (diacylglycerol), a product of PtdIns(4,5)P2 hydrolysis by PLC (phospholipase C). In addition to its well-known function as a protein kinase C activator, DAG produced by stimulation of the epidermal growth factor receptor causes the redistribution of the Rac-GAP (GTPase-activating protein) β2-chimaerin to the plasma membrane, where it associates with the active form of Rac1 and promotes the inactivation of this small G-protein. This represents the first example of a Rac-GAP regulated directly by DAG in response to the activation of a tyrosine kinase receptor, and suggests a previously unappreciated role for this lipid as a negative modulator of Rac signalling.
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Conference Article| October 25 2006
The lipid second messenger diacylglycerol as a negative regulator of Rac signalling
M.G. Kazanietz 1
1Department of Pharmacology, University of Pennsylvania School of Medicine, 816 BRB II/III, 421 Curie Blvd, Philadelphia, PA 19104-6160, U.S.A.
1To whom correspondence should be addressed (email firstname.lastname@example.org).
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H. Wang, M.G. Kazanietz; The lipid second messenger diacylglycerol as a negative regulator of Rac signalling. Biochem Soc Trans 1 October 2006; 34 (5): 855–857. doi: https://doi.org/10.1042/BST0340855
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