5-HT3 receptors are members of the Cys-loop superfamily of ligand-gated ion channels. In both the central and the peripheral nervous systems, 5-HT3 receptors excite postsynaptic cells and modulate the release of neurotransmitters from presynaptic neurons. 5-HT3 receptors are known to be involved in mediation of nausea/emesis caused by chemo/radio-therapy and anaesthesia, and more recently have also been found to be involved in irritable bowel syndrome. 5-HT3 receptors have also been suggested to play a role in a range of other indications, including various psychiatric disorders. This review summarizes the current evidence for the contribution of 5-HT3 subunit genes to disease phenotypes arising from association studies. Furthermore, it suggests how in vitro characterization of naturally occurring genetic variants can be used to obtain a better understanding of the causal relationship between gene and disease.
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Conference Article| October 25 2006
Do polymorphisms in the human 5-HT3 genes contribute to pathological phenotypes?
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K. Krzywkowski; Do polymorphisms in the human 5-HT3 genes contribute to pathological phenotypes?. Biochem Soc Trans 1 October 2006; 34 (5): 872–876. doi: https://doi.org/10.1042/BST0340872
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