AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptor trafficking is a fundamental mechanism for regulating synaptic strength, and hence may underlie cellular processes involved in learning and memory. PICK1 (protein that interacts with protein C-kinase) has recently emerged as a key regulator of AMPAR (AMPA receptor) traffic, and the precise molecular mechanisms of PICK1's action are just beginning to be unravelled. In this review, I summarize recent findings that describe some important molecular characteristics of PICK1 with respect to AMPAR cell biology.
Conference Article| October 25 2006
Molecular mechanisms for regulation of AMPAR trafficking by PICK1
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J.G. Hanley; Molecular mechanisms for regulation of AMPAR trafficking by PICK1. Biochem Soc Trans 1 October 2006; 34 (5): 931–935. doi: https://doi.org/10.1042/BST0340931
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