An understanding of the mechanism of ATP synthase requires an explanation of how inhibitors act. The catalytic F1-ATPase domain of the enzyme has been studied extensively by X-ray crystallography in a variety of inhibited states. Four independent inhibitory sites have been identified by high-resolution structural studies. They are the catalytic site, and the binding sites for the antibiotics aurovertin and efrapeptin and for the natural inhibitor protein, IF1.
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Conference Article| October 25 2006
Inhibitors of the catalytic domain of mitochondrial ATP synthase
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J.R. Gledhill, J.E. Walker; Inhibitors of the catalytic domain of mitochondrial ATP synthase. Biochem Soc Trans 1 October 2006; 34 (5): 989–992. doi: https://doi.org/10.1042/BST0340989
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