The general transcription factor TFIIB (transcription factor IIB) plays a critical role in the assembly of the RNA polymerase II pre-initiation complex. TFIIB can make sequence-specific DNA contacts both upstream and downstream of the TATA box. This has led to the definition of two core promoter BREs (TFIIB-recognition elements), one upstream [BREu (upstream BRE)] and one downstream of TATA box [BREd (downstream BRE)]. TFIIB–BREu and TFIIB–BREd contacts are mediated by two independent DNA-recognition motifs within the core domain of TFIIB. Both the BREu and the BREd modulate the transcriptional potency of a promoter. However, the net effect of the BREs on promoter activity is dependent on the specific blend of elements present within a core promoter.
Conference Article| October 25 2006
Core promoter elements recognized by transcription factor IIB
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W. Deng, S.G.E. Roberts; Core promoter elements recognized by transcription factor IIB. Biochem Soc Trans 1 December 2006; 34 (6): 1051–1053. doi: https://doi.org/10.1042/BST0341051
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