Genetics and biochemistry have been exploited to investigate transcription activation by the Escherichia coli CRP (cAMP receptor protein) factor at promoters with a DNA site for CRP near position −41 and the effects of a second upstream-bound CRP molecule. We show that the upstream-bound CRP contributes to transcription activation by improving the recruitment of RNA polymerase.
Recruitment of RNA polymerase to Class II CRP-dependent promoters is improved by a second upstream-bound CRP molecule
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N.S. Miroslavova, J.E. Mitchell, J. Tebbutt, S.J.W. Busby; Recruitment of RNA polymerase to Class II CRP-dependent promoters is improved by a second upstream-bound CRP molecule. Biochem Soc Trans 1 December 2006; 34 (6): 1075–1078. doi: https://doi.org/10.1042/BST0341075
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