Ribosome assembly occurs co-transcriptionally on the rRNA genes. This process requires the co-ordinated expression and assembly of many hundreds of proteins and is finely tuned to cell and organism growth. Co-ordinate regulation of the rRNA genes and the ribosomal protein genes is therefore essential for high-fidelity ribosome assembly. Recent work shows that rRNA gene transcription is regulated at the level of elongation via the mitogen-activated protein kinase pathway. We argue that this may provide an explanation for the high fidelity of ribosome assembly.
Conference Article| October 25 2006
A new paradigm for the regulation of the mammalian ribosomal RNA genes
T. Moss 1
1Cancer Research Centre and Department of Medical Biology, Laval University, CHUQ-HDQ, Pavillon St. Patrick, 9 rue McMahon, QC, Canada G1R 3S3
1To whom correspondence should be addressed (email Tom.Moss@crhdq.ulaval.ca).
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T. Moss, V. Stefanovsky, F. Langlois, T. Gagnon-Kugler; A new paradigm for the regulation of the mammalian ribosomal RNA genes. Biochem Soc Trans 1 December 2006; 34 (6): 1079–1081. doi: https://doi.org/10.1042/BST0341079
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