Cannabinoids have been shown to possess anti-inflammatory and neuroprotective properties, which were proposed to occur mainly via activation of the G-protein-coupled receptor CB1 (cannabinoid receptor 1). Recently, certain cannabinoids have been reported to be ligands for members of the nuclear receptor transcription factor superfamily known as PPARs (peroxisome-proliferator-activated receptors). This review summarizes the evidence for cannabinoid activation of PPARs and identifies a new intracellular target for cannabinoids as therapeutic agents for neuroprotective treatment.
Conference Article| October 25 2006
Cannabinoids and PPARα signalling
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Y. Sun, S.P.H. Alexander, D.A. Kendall, A.J. Bennett; Cannabinoids and PPARα signalling. Biochem Soc Trans 1 December 2006; 34 (6): 1095–1097. doi: https://doi.org/10.1042/BST0341095
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