Nur77 is a nuclear orphan receptor that has been implicated in both cell survival and apoptosis. With the exception of T-cells, translocation of Nur77 to the cytoplasm promotes cell death, while its retention in the nucleus promotes survival and proliferation. Nur77 appears to be a true orphan receptor, indicating that its activity must be controlled by ligand-independent mechanisms. Here, we discuss the role of phosphorylation in the regulation of Nur77.
Conference Article| October 25 2006
Post-translational control of Nur77
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A.D. Wingate, J.S.C. Arthur; Post-translational control of Nur77. Biochem Soc Trans 1 December 2006; 34 (6): 1107–1109. doi: https://doi.org/10.1042/BST0341107
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