PPARs (peroxisome-proliferator-activated receptors) and LXRs (liver X receptors) are ligand-activated transcription factors that control lipid and glucose metabolism, as well as the inflammatory response. Since the macrophage plays an important role in host defence and immuno-inflammatory pathologies, particular attention has been paid to the role of PPARs and LXRs in the control of macrophage gene expression and function. Altered macrophage functions contribute to the pathogenesis of many infectious, immunological and inflammatory disease processes, including atherosclerosis. Research over the last few years has revealed important roles for PPARs and LXRs in macrophage inflammation and cholesterol homoeostasis with consequences in atherosclerosis development. This review will discuss the role of these transcription factors in the control of cholesterol trafficking in macrophages.
Conference Article| October 25 2006
Transcriptional regulation of macrophage cholesterol trafficking by PPARα and LXR
B. Staels 1
*INSERM U545, Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP 245, 59019 Lille, France
†Université de Lille 2, Faculté de Pharmacie, 3 rue du Professeur Laguesse, BP 83, 59006 cedex Lille, France
1To whom correspondence should be addressed (email firstname.lastname@example.org).
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G. Chinetti, J.C. Fruchart, B. Staels; Transcriptional regulation of macrophage cholesterol trafficking by PPARα and LXR. Biochem Soc Trans 1 December 2006; 34 (6): 1128–1131. doi: https://doi.org/10.1042/BST0341128
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