In several experimental studies of cerebral ischaemia, G-CSF (granulocyte colony-stimulating factor) exerted neuroprotective effects through different mechanisms, including mobilization of haemopoietic stem cells, anti-apoptosis, neuronal differentiation, angiogenesis and anti-inflammation. Hence, G-CSF not only inhibits neuron death, but also generates ‘new’ neural tissue formation. A small pilot trial reports on the safety and feasibility of G-CSF therapy in stroke patients. According to this evidence, we can speculate that G-CSF, being used either alone or in combination with another agent, should have a dual activity beneficial both to acute neuronal protection and long-term plasticity after cerebral ischaemia, thus proposing that G-CSF is an ideal new drug for stroke and neurodegenerative diseases.
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Conference Article|
October 25 2006
G-CSF and neuroprotection: a therapeutic perspective in cerebral ischaemia
C.-Z. Lu;
C.-Z. Lu
1
1Institute of Neurology, Huashan Hospital, Institute of Brain Science, University of Fudan, 12 Middle Wulumuqi Road, 200040 Shanghai, People's Republic of China
1To whom correspondence should be addressed (email [email protected]).
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B.-G. Xiao
B.-G. Xiao
1Institute of Neurology, Huashan Hospital, Institute of Brain Science, University of Fudan, 12 Middle Wulumuqi Road, 200040 Shanghai, People's Republic of China
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Publisher: Portland Press Ltd
Received:
July 20 2006
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2006 The Biochemical Society
2006
Biochem Soc Trans (2006) 34 (6): 1327–1333.
Article history
Received:
July 20 2006
Citation
C.-Z. Lu, B.-G. Xiao; G-CSF and neuroprotection: a therapeutic perspective in cerebral ischaemia. Biochem Soc Trans 1 December 2006; 34 (6): 1327–1333. doi: https://doi.org/10.1042/BST0341327
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