The identification of the biological functions of TRP (transient receptor potential) proteins requires genetic approaches because a selective TRP channel pharmacology to unravel the roles of TRPs is not available so far for most TRPs. A survey is therefore presented of transgenic animal models carrying mutations in TRP genes, as well as of those TRP genes that when mutated result in human disease; the chromosomal locations of TRP channel genes in the human and mouse are also presented.
Conference Article| January 22 2007
Biological functions of TRPs unravelled by spontaneous mutations and transgenic animals
M. Freichel 1
1Experimentelle und Klinische Pharmakologie und Toxikologie, Gebäude 46, Medizinische Fakultät, Universität des Saarlandes, 66421 Homburg, Germany
1To whom correspondence should be addressed (email email@example.com).
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M. Freichel, V. Flockerzi; Biological functions of TRPs unravelled by spontaneous mutations and transgenic animals. Biochem Soc Trans 1 February 2007; 35 (1): 120–123. doi: https://doi.org/10.1042/BST0350120
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