This short review provides a broad, and therefore necessarily incomplete and personal, overview of G-protein-coupled receptors, which are often targets for a wide range of important drugs: I will discuss successively their structure, function and interactions with associated proteins. Examples will be drawn from work done over the last 30 years by scientists that worked at different times in my laboratories, mainly in the field of β-adrenoceptors, muscarinic acetylcholine, melatonin and angiotensin receptors.
Discussion| January 22 2007
G-protein-coupled receptor signalling through protein networks
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A.D. Strosberg, C. Nahmias; G-protein-coupled receptor signalling through protein networks. Biochem Soc Trans 1 February 2007; 35 (1): 23–27. doi: https://doi.org/10.1042/BST0350023
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