This review focuses on the recognition properties of protein kinases at the molecular level. Phosphorylation of the substrate protein by a protein kinase can result in enzyme activation or inhibition, conformational changes that change recognition properties, or the creation of a surface with distinct binding properties. Protein kinases have become important targets for the development of inhibitors with potential therapeutic application. Various examples are considered in this review, and I discuss our own work on glycogen phosphorylase and phosphorylase kinase, and the structures of proteins involved with the cell cycle, including cyclins and cyclin-dependent kinases.
Discussion| January 22 2007
Protein kinases and their therapeutic exploitation
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L. Johnson; Protein kinases and their therapeutic exploitation. Biochem Soc Trans 1 February 2007; 35 (1): 7–11. doi: https://doi.org/10.1042/BST0350007
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