Calcium channels play important roles in cellular signalling. TRP (transient receptor potential) channels form a superfamily of calcium channels through which Ca2+ enters the cell. TRPs have six transmembrane segments with a putative pore between the fifth and the sixth segments, and assemble in tetrameric complexes to form functional Ca2+ channels. They are thus similar to KV (voltage-gated potassium channel) channels in terms of structure and molecular determinants that promote subunit assembly. In this review, the molecular determinants mediating the assembly of Drosophila TRP, TRPC (TRP canonical), TRPV (TRP vanilloid) and KV channels are described.
Conference Article| January 22 2007
Molecular determinants of TRP channel assembly
G. Boulay 1
Département de Pharmacologie, Faculté de Médecine et Sciences de la Santé, Université de Sherbrooke, 3001–12e avenue Nord, Sherbrooke, QC, Canada J1H 5N4
1To whom correspondence should be addressed (email Guylain.Boulay@USherbrooke.ca).
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P.K. Lepage, G. Boulay; Molecular determinants of TRP channel assembly. Biochem Soc Trans 1 February 2007; 35 (1): 81–83. doi: https://doi.org/10.1042/BST0350081
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