PI3Ks (phosphoinositide 3-kinases) regulate diverse cellular functions such as metabolism, growth, gene expression and migration. The p110δ isoform of PI3K is mainly expressed in cells of the immune system and contributes to cellular and humoral immunity. In the thymus, p110δ and p110γ play complementary roles in regulating the transition through key developmental checkpoints. In addition, p110δ regulates the differentiation of peripheral Th (helper T-cells) towards the Th1 and Th2 lineages. Moreover, p110δ is critical for Treg (regulatory T-cell) function. Here, we review the role of PI3Ks in T-cell development and function.
Keywords:colitis, forkhead box O (Foxo), p110δ, phosphoinositide 3-kinase (PI3K), T-cell, thymocyte
© 2007 The Biochemical Society