Recent work has demonstrated that the PI3K (phosphoinositide 3-kinase) signalling pathway is important for efficient influenza A virus replication. Activation of PI3K in virus-infected cells is mediated by the viral NS1 protein, which binds directly to the p85β regulatory subunit of PI3K and causes the PI3K-dependent phosphorylation of Akt (protein kinase B). Given that recombinant influenza A viruses unable to activate PI3K signalling are attenuated in tissue culture, the PI3K pathway could be a novel target for the development of future anti-influenza drugs.
Conference Article| March 20 2007
PI3K signalling during influenza A virus infections
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B.G. Hale, R.E. Randall; PI3K signalling during influenza A virus infections. Biochem Soc Trans 1 April 2007; 35 (2): 186–187. doi: https://doi.org/10.1042/BST0350186
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