Activation of the enzyme PLC (phospholipase C) leads to the formation of second messengers Ins(1,4,5)P3 and diacylglycerol. RTKs (receptor tyrosine kinases) activate this reaction through PLCγ isoenzymes. It has been shown that PI3K (phosphoinositide 3-kinase) may regulate PLCγ activity through the interaction of PI3K product PtdIns(3,4,5)P3 and the PLCγ PH domain (pleckstrin homology domain). Here, we analyse the potential functional roles of the PI3K/PLC pathway.
Conference Article| March 20 2007
Phosphoinositide 3-kinase-dependent regulation of phospholipase Cγ
T. Maffucci 1
1Centre for Cardiovascular Biology and Medicine, Division of Medicine, The Rayne Institute, University College London, 5 University Street, London WC1E 6JJ, U.K.
1To whom correspondence should be addressed (email firstname.lastname@example.org).
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T. Maffucci, M. Falasca; Phosphoinositide 3-kinase-dependent regulation of phospholipase Cγ. Biochem Soc Trans 1 April 2007; 35 (2): 229–230. doi: https://doi.org/10.1042/BST0350229
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