The design and synthesis of SpmTrien (1,12-diamino-3,6,9-triazadodecane), an isosteric and charge-deficient analogue of spermine with excellent chelating properties towards Cu2+ ions, as well as novel N1- and N12-Ac-SpmTriens and bis-Et-SpmTrien (N1,N12-diethyl-1,12-diamino-3,6,9-triazadodecane) are described. Possible applications of SpmTrien and its derivatives to the investigation of the enzymes of polyamine metabolism and spermine cellular functions, including interaction with DNA, are discussed.
Novel approach to design an isosteric charge-deficient analogue of spermine and its biochemically important derivatives
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A.R. Khomutov, N.A. Grigorenko, S.G. Skuridin; Novel approach to design an isosteric charge-deficient analogue of spermine and its biochemically important derivatives. Biochem Soc Trans 1 April 2007; 35 (2): 369–373. doi: https://doi.org/10.1042/BST0350369
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