In early atherosclerosis the frequency of activated monocytes in the peripheral circulation is amplified, and migration of monocytes into the walls of the aorta and large arteries is increased, due partly to de novo expression or activation of monocyte adhesion molecules. Although there is increasing evidence that CMRs (chylomicron remnants) are strongly atherogenic, the outcomes of interactions between blood monocytes and circulating CMRs are not known. Here, we have studied the effects of CRLPs (CMR-like particles) on THP-1 human monocyte oxidative burst. The particles induced a significant increase in reactive oxygen species within 1 h, which persisted for 24 h. We suggest that monocyte–CMR interactions may be important in early atherosclerosis when many activated monocytes are found in susceptible areas of the artery wall.
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June 2007
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Conference Article|
May 22 2007
Dietary fats induce human monocyte activation in vitro
C. Bentley;
C. Bentley
1Veterinary Basic Sciences, The Royal Veterinary College, Royal College Street, London NW1 0TU, U.K.
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F. Bejta;
F. Bejta
1Veterinary Basic Sciences, The Royal Veterinary College, Royal College Street, London NW1 0TU, U.K.
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C. De Pascale;
C. De Pascale
1Veterinary Basic Sciences, The Royal Veterinary College, Royal College Street, London NW1 0TU, U.K.
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M. Avella;
M. Avella
1Veterinary Basic Sciences, The Royal Veterinary College, Royal College Street, London NW1 0TU, U.K.
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C.P.D. Wheeler-Jones;
C.P.D. Wheeler-Jones
1Veterinary Basic Sciences, The Royal Veterinary College, Royal College Street, London NW1 0TU, U.K.
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K.M. Botham;
K.M. Botham
1Veterinary Basic Sciences, The Royal Veterinary College, Royal College Street, London NW1 0TU, U.K.
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C. Lawson
C. Lawson
1
1Veterinary Basic Sciences, The Royal Veterinary College, Royal College Street, London NW1 0TU, U.K.
1To whom correspondence should be addressed (email [email protected]).
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Publisher: Portland Press Ltd
Received:
December 20 2006
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2007 Biochemical Society
2007
Biochem Soc Trans (2007) 35 (3): 464–465.
Article history
Received:
December 20 2006
Citation
C. Bentley, F. Bejta, C. De Pascale, M. Avella, C.P.D. Wheeler-Jones, K.M. Botham, C. Lawson; Dietary fats induce human monocyte activation in vitro. Biochem Soc Trans 1 June 2007; 35 (3): 464–465. doi: https://doi.org/10.1042/BST0350464
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