Unregulated apoptosis can be due to a disruption in the balance and control of both intra- and inter-cellular proteolytic activities leading to various disease states. Many proteases involved in apoptotic processes are yet to be identified; however, several are already well characterized. Caspases traditionally held the predominant role as prime mediators of execution. However, latterly, evidence has accumulated that non-caspases, including calpains, cathepsins, granzymes and the proteasome have roles in mediating and promoting cell death. Increasingly, research is implicating serine proteases within apoptotic processing, particularly in the generation of nuclear events such as condensation, fragmentation and DNA degradation observed in late-stage apoptosis. Serine proteases therefore are emerging as providing additional or alternative therapeutic targets.
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June 2007
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Conference Article|
May 22 2007
The emerging role of serine proteases in apoptosis
K.L. Moffitt;
K.L. Moffitt
1
1School of Pharmacy, Queen's University, Belfast BT9 7BL, Northern Ireland, U.K.
1To whom correspondence should be addressed (email [email protected]).
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S.L. Martin;
S.L. Martin
1School of Pharmacy, Queen's University, Belfast BT9 7BL, Northern Ireland, U.K.
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B. Walker
B. Walker
1School of Pharmacy, Queen's University, Belfast BT9 7BL, Northern Ireland, U.K.
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Publisher: Portland Press Ltd
Received:
January 08 2007
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2007 Biochemical Society
2007
Biochem Soc Trans (2007) 35 (3): 559–560.
Article history
Received:
January 08 2007
Citation
K.L. Moffitt, S.L. Martin, B. Walker; The emerging role of serine proteases in apoptosis. Biochem Soc Trans 1 June 2007; 35 (3): 559–560. doi: https://doi.org/10.1042/BST0350559
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