Statins inhibit the dimerization of β-secretase [BACE (β-site amyloid precursor protein-cleaving enzyme)] by inhibiting the lipidation of BACE and associated proteins. Our studies have demonstrated a clearly defined temporal sequence for these reactions in the assembly of the BACE complex, which may provide targets for the treatment of Alzheimer's disease.
Conference Article| May 22 2007
Regulation of the lipidation of β-secretase by statins
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R.B. Parsons, J.K. Farrant, G.C. Price, D. Subramaniam, B.M. Austen; Regulation of the lipidation of β-secretase by statins. Biochem Soc Trans 1 June 2007; 35 (3): 577–582. doi: https://doi.org/10.1042/BST0350577
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