Elaborate non-random organization of human sperm chromosomes at different structural levels, starting from the DNA packing by protamines up to the higher-order chromosome configuration and nuclear positioning of chromosome territories, has been discovered. Here, we put forward a hypothesis that the unique genome architecture in sperm provides a mechanism for orchestrated unpacking and ordered activation of the male genome during fertilization, thus offering an additional level of epigenetic information that will be deciphered in the descendant cells.
Conference Article| May 22 2007
Organization of chromosomes in spermatozoa: an additional layer of epigenetic information?
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A. Zalensky, I. Zalenskaya; Organization of chromosomes in spermatozoa: an additional layer of epigenetic information?. Biochem Soc Trans 1 June 2007; 35 (3): 609–611. doi: https://doi.org/10.1042/BST0350609
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