In dissecting the molecules and molecular mechanisms that control mammalian oocyte-to-embryo transition, we found abundant transcripts representing developmentally regulated ERVs (endogenous retroviruses) in mouse oocyte and two-cell stage embryo cDNA libraries. These retrotransposons can act as alternative promoters and first exons for diverse genes, synchronizing their expression. Heritable genetic change due to replication of these retrotransposons probably occurs specifically in oocytes and early embryos. ERVs are usually epigenetically silenced, through DNA methylation and chromatin-based mechanisms. Their activation and silencing indicates a change in the epigenetic state of the genome. The thousands of endogenous retro-elements in the mouse genome provides potential scope for large-scale co-ordinated epigenetic fluctuations and leads to the hypothesis that differential transposable element expression triggers sequential reprogramming of the embryonic genome during the oocyte-to-embryo transition.
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June 2007
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Conference Article|
May 22 2007
Genome plasticity in the mouse oocyte and early embryo
A.E. Peaston;
A.E. Peaston
1
*The Jackson Laboratory, Bar Harbor, ME 04609, U.S.A.
1To whom correspondence should be addressed (email [email protected]).
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B.B. Knowles;
B.B. Knowles
*The Jackson Laboratory, Bar Harbor, ME 04609, U.S.A.
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K.W. Hutchison
K.W. Hutchison
*The Jackson Laboratory, Bar Harbor, ME 04609, U.S.A.
†Department of Biochemistry, Microbiology and Molecular Biology, The University of Maine, Orono, ME 04469, U.S.A.
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Publisher: Portland Press Ltd
Received:
November 13 2006
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2007 Biochemical Society
2007
Biochem Soc Trans (2007) 35 (3): 618–622.
Article history
Received:
November 13 2006
Citation
A.E. Peaston, B.B. Knowles, K.W. Hutchison; Genome plasticity in the mouse oocyte and early embryo. Biochem Soc Trans 1 June 2007; 35 (3): 618–622. doi: https://doi.org/10.1042/BST0350618
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