Aided by mice with multiple deleted brain matrix protein genes, the biochemical analysis of mouse brain matrix molecules indicates a constitutive production of more proteoglycans than can be integrated in multimolecular matrix structures. Possible functions of non-matrix integrated proteoglycans, and aspects of incomplete compensatory mechanisms in knockout mice are discussed.

Keywords:
a disintegrin and metalloprotease with thrombospondin motifs (ADAMTS), brain matrix, fibulin, lectican, link protein, tenascin
© The Authors Journal compilation © 2007 Biochemical Society
2007
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