The CNS (central nervous system) has a unique pattern of immune response to infection. TB (tuberculosis) of the CNS is devastating with widespread tissue destruction. In TB, astrocyte–leucocyte interactions are key in regulating MMP (matrix metalloproteinase) activity and are regulated by complex signalling pathways. A synergistic interaction between interferon γ and monocyte-derived mediators drives high-level astrocyte MMP-9 secretion; this and other networking effects are inhibited by steroids. Better understanding of regulatory mechanisms may identify potential switch points that could be future therapeutic targets.
Conference Article| July 20 2007
Astrocyte–leucocyte interactions and the mechanisms regulating matrix degradation in CNS tuberculosis
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J.A. Green, J.S. Friedland; Astrocyte–leucocyte interactions and the mechanisms regulating matrix degradation in CNS tuberculosis. Biochem Soc Trans 1 August 2007; 35 (4): 686–688. doi: https://doi.org/10.1042/BST0350686
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