Recently, it was found that Bcl-2 family proteins can affect the apoptotic process by modifying Ca2+ released from the ER (endoplasmic reticulum). In this review, we summarize the evidence that Bcl-2 and Bax can modulate Ca2+ mobilization from the ER to the cytosol and mitochondria. We also found evidence that both Bcl-2 and Bax can interact with IP3Rs (InsP3 receptors) to modify the Ca2+ efflux from the ER. On the basis of our findings, we suggest that Bax may interact with IP3Rs to facilitate the release of Ca2+ from the ER during apoptosis.
Conference Article| October 25 2007
Study of the functional role of Bcl-2 family proteins in regulating Ca2+ signals in apoptotic cells
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Y. Lao, D.C. Chang; Study of the functional role of Bcl-2 family proteins in regulating Ca2+ signals in apoptotic cells. Biochem Soc Trans 1 November 2007; 35 (5): 1038–1039. doi: https://doi.org/10.1042/BST0351038
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