Plasma membrane translocation, following allosteric binding of second messengers, initiates the signal transduction process mediated by cPKC [conventional PKC (protein kinase C)] isotypes. Mechanisms regulating the lifespan of the active enzyme such as its phosphorylation, internalization, dephosphorylation and degradation are key elements of the signalling network. The understanding of such mechanisms is essential for the design of therapeutic strategies targeting PKC isoenzymes.
Conference Article| October 25 2007
Lifespan regulation of conventional protein kinase C isotypes
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D. Carmena, A. Sardini; Lifespan regulation of conventional protein kinase C isotypes. Biochem Soc Trans 1 November 2007; 35 (5): 1043–1045. doi: https://doi.org/10.1042/BST0351043
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