The proper trafficking and localization of cardiac potassium channels is profoundly important to the regulation of the regionally distinct action potentials across the myocardium. These processes are only beginning to be unravelled and involve modulators of channel synthesis and assembly, post-translational processing, various molecular motors and an increasing number of modifying enzymes and molecular anchors. The roles of anchoring proteins, molecular motors and kinases are explored and recent findings on channel internalization and trafficking are presented.
Conference Article| October 25 2007
Localization and trafficking of cardiac voltage-gated potassium channels
A. Dehghani Zadeh;
D. Fedida 2
1Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, Canada V6T 1Z3
2To whom correspondence should be addressed (email firstname.lastname@example.org).
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D.F. Steele, A. Dehghani Zadeh, M.E. Loewen, D. Fedida; Localization and trafficking of cardiac voltage-gated potassium channels. Biochem Soc Trans 1 November 2007; 35 (5): 1069–1073. doi: https://doi.org/10.1042/BST0351069
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