Cerebral ischaemia results in the activation of three isoforms of NOS (nitric oxide synthase) that contribute to the development of and recovery from stroke pathology. This review discusses, in particular, the role of the transcriptionally activated NOS-2 (inducible NOS) isoform and summarizes the outcomes of experimental stroke studies with regard to the therapeutic utility of nitric oxide donors and NOS inhibitors.
Conference Article| October 25 2007
Nitric oxide, ischaemia and brain inflammation
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S. Murphy, C.L. Gibson; Nitric oxide, ischaemia and brain inflammation. Biochem Soc Trans 1 November 2007; 35 (5): 1133–1137. doi: https://doi.org/10.1042/BST0351133
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