Insulin has a potent inhibitory effect on hepatic glucose production by direct action at hepatic receptors. The hormone also inhibits glucose production by suppressing both lipolysis in the fat cell and secretion of glucagon by the α-cell. Neural sensing of insulin levels appears to participate in control of hepatic glucose production in rodents, but a role for brain insulin sensing has not been documented in dogs or humans. The primary effect of insulin on the liver is its direct action.
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Conference Article| October 25 2007
Insulin action on the liver in vivo
A.D. Cherrington ;
A.D. Cherrington 1
1Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 704 Robinson Research Bldg, Nashville, TN 37232-0615, U.S.A.
1To whom correspondence should be addressed (email firstname.lastname@example.org).
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M.C. Moore ;
D.K. Sindelar ;
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A.D. Cherrington, M.C. Moore, D.K. Sindelar, D.S. Edgerton; Insulin action on the liver in vivo. Biochem Soc Trans 1 November 2007; 35 (5): 1171–1174. doi: https://doi.org/10.1042/BST0351171
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