In metazoans, accurate replication of chromosomes is ensured by the coupling of DNA synthesis to the synthesis of histone proteins. Expression of replication-dependent histone genes is restricted to S-phase by a combination of cell cycle-regulated transcriptional and post-transcriptional control mechanisms and is linked to DNA replication by a poorly understood mechanism involving checkpoint kinases [Su, Gao, Schneider, Helt, Weiss, O'Reilly, Bohmann and Zhao (2004) EMBO J. 23, 1133–1143; Kaygun and Marzluff (2005) Nat. Struct. Mol. Biol. 12, 794–800]. Here we propose a model for the molecular mechanisms that link these two important processes within S-phase, and propose roles for multiple checkpoints in this mechanism.
Are multiple checkpoint mediators involved in a checkpoint linking histone gene expression with DNA replication?
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B. Müller, J. Blackburn, C. Feijoo, X. Zhao, C. Smythe; Are multiple checkpoint mediators involved in a checkpoint linking histone gene expression with DNA replication?. Biochem Soc Trans 1 November 2007; 35 (5): 1369–1371. doi: https://doi.org/10.1042/BST0351369
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