The PMCA (plasma-membrane Ca2+-ATPase) is a ubiquitously expressed calcium-extruding enzymatic pump important in the control of intracellular calcium concentration. Unlike in non-excitable cells, where PMCA is the only system for calcium extrusion, in excitable cells, such as cardiomyocytes, PMCA has been shown to play only a minor role in calcium homoeostasis compared with the NCX (sodium/calcium exchanger), another system of calcium extrusion. However, increasing evidence points to an important role for PMCA in signal transduction; of particular interest in cardiac physiology is the modulation of nNOS (neuronal nitric oxide synthase) by isoform 4b of PMCA. In the present paper, we will discuss recent advances that support a key role for PMCA4 in modulating the nitric oxide signalling pathway in the heart.
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Conference Article| October 25 2007
The regulatory function of plasma-membrane Ca2+-ATPase (PMCA) in the heart
L. Neyses 1
1Division of Cardiovascular Sciences, University of Manchester, Manchester M13 9PT, U.K.
1To whom correspondence should be addressed, at Division of Cardiovascular Sciences, University of Manchester, Room 1.302, Stopford Building, Oxford Road, Manchester M13 9PT, U.K. (email Ludwig.Neyses@cmmc.nhs.uk).
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D. Oceandy, P.J. Stanley, E.J. Cartwright, L. Neyses; The regulatory function of plasma-membrane Ca2+-ATPase (PMCA) in the heart. Biochem Soc Trans 1 November 2007; 35 (5): 927–930. doi: https://doi.org/10.1042/BST0350927
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