Attachment of the SUMO (small ubiquitin-related modifier) to the replication factor PCNA (proliferating-cell nuclear antigen) in the budding yeast has been shown to recruit a helicase, Srs2, to active replication forks, which in turn prevents unscheduled recombination events. In the present review, I will discuss how the interaction between SUMOylated PCNA and Srs2 serves as an example for a mechanism by which SUMO modulates the properties of its targets and mediates the activation of downstream effector proteins.
Conference Article| November 23 2007
PCNASUMO and Srs2: a model SUMO substrate–effector pair
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H.D. Ulrich; PCNASUMO and Srs2: a model SUMO substrate–effector pair. Biochem Soc Trans 1 December 2007; 35 (6): 1385–1388. doi: https://doi.org/10.1042/BST0351385
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